Plataforma multifuncional nanoestructurada para entrega secuencial de moléculas terapéuticas
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González-Jiménez, E. E. (2022). Plataforma multifuncional nanoestructurada para entrega secuencial de moléculas terapéuticas. Revista De La Academia Colombiana De Ciencias Exactas, Físicas Y Naturales, 46(179), 339–355. https://doi.org/10.18257/raccefyn.1660

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A partir de nanocajas metálicas de doble pared con un monoporo (DWSPNb) sintetizadas por efecto Kirkendall y reemplazo galvánico, se propone una plataforma multifuncional nanoestructurada con capacidad de liberación secuencial de agentes moleculares para uso terapéutico. La evaluación de la plataforma propuesta se hizo mediante cálculo numérico basado en las dimensiones, morfología y composición de las nanocajas sintetizadas. Para las combinaciones de dos moléculas farmacológicas de interés, se determinaron los coeficientes de difusión en función de la distancia a las paredes de la nanocaja y la concentración. La simulación realizada para la liberación de las dos moléculas de la cavidad interna a través del nanocanal formado entre las dos paredes de la nanocaja evidenció la cinética secuencial requerida. Este comportamiento permite programar entregas controladas en tiempo y lugar para reducir la resistencia a los fármacos duales y, consecuentemente, optimizar la dosis necesaria y evitar los efectos secundarios derivados. La composición metálica convirtió la nanocaja en una nanoantena optotérmica, lo que permite controlar la liberación y entrega de la carga molecular a través de polímeros sensibles a la temperatura, además de su uso potencial para tratamientos fotodinámicos y diagnósticos por imagen.

https://doi.org/10.18257/raccefyn.1660

Palabras clave

Nanoplataforma | Entrega secuencial | Nanocajas | Liberación de medicamentos | Nanoantenas | Difusión molecular
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Referencias

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