Characterization of the non-covalent conjugate graphene-folic acid using Raman spectroscopy and computational methods
Portada 42 (162) 2018
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Castillo, J. J., Orduz, A. E., & Rozo, C. E. (2018). Characterization of the non-covalent conjugate graphene-folic acid using Raman spectroscopy and computational methods. Revista De La Academia Colombiana De Ciencias Exactas, Físicas Y Naturales, 42(162), 96–103. https://doi.org/10.18257/raccefyn.524

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Abstract

Hybrid compounds formed by biomolecules and nanometric structures are attracting interest for the development of applications in the fields of biosensors and drug delivery. In this study we prepared a grapheme-folic acid conjugate which we characterized by Raman spectroscopy and the density functional theory (DFT) computational method. The non-covalent conjugate was performed through a simple and fast one-pot method. The analysis of ratio intensity of D and G bands in the Raman spectroscopy evidenced graphene functionalization. The DFT method showed that the bond between graphene and folic acid occurs by non-covalent π-π and hydrogen bond interactions. Graphene and folic acid conjugates will allow the design of biosensors for the detection of cancer cells overexpressing folate receptors using analytic devices for a faster, more effective and timely diagnosis of cancer. © 2018. Acad. Colomb. Cienc. Ex. Fis. Nat
https://doi.org/10.18257/raccefyn.524
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Caracterización del conjugado no covalente grafeno-ácido fólico 103

doi: http://dx.doi.org/10.18257/raccefyn.524 Rev. Acad. Colomb. Cienc. Ex. Fis. Nat. 42(162):96-103, enero-marzo de 2018

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