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The origin, function and repertoire of human IgM memory B cells (IgM mBc, characterized by the expression of CD27+ IgM+ IgD+ ) are controversial, and it has been proposed that this population is heterogeneous. Although contradictory in some cases, available evidence suggests that at least two subpopulations of IgM mBc circulate in blood. On the one hand, circulating B cells from the marginal zone of the spleen with innate-like characteristics, probably responsible for protective responses against encapsulated bacteria like Streptococcus sp. On the other hand, B cells with markers that suggest they have undergone transit in germinal centers, typical of adaptive immunity, and that may represent a reservoir of long-lived mBc capable of reconstituting switched mBc. It has been proposed that the differential expression of IgM and IgD on circulating IgM mBc may be useful to distinguish these subpopulations, but more phenotypic and functional studies are needed for this purpose. © 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. All rights reserved.References
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