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Abstract
Based on C. J. Gadjusek own observations and on B. Sigurdsson proposals, they described the slow virus etiology for these entities. We state that, as far as we know nowadays, the priondemency relationship is limited to the Creutzfeldt-Jakob disease and according to recent evidence, especially to the atypical form. The etiological approach to these entities changed around 1982-1984 when Stanley Prusiner introduced the prion concept. The entities actually considered to be of prionic origin are succinctly described, paying special attention to bovine spongiform encephalitis, colloquially called as "crazy cows". Citing Domich, there is the possibility of a greater frecuency of these entities that what is known up to these present.
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