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Abstract
Nutrition is a determinant of the immune response and deficits in protein and calories have deleterious effects on host defense systems. The relationship among nutrition, migration and resistance to infection is very complex. Chemotaxis or cell migration is a basic fenomena for both physiological and pathological processes. Stromal-derived factor-1 (SDF-1) or CXCL12 chemokine and its receptor CXCR4 are important regulators of hematopoiesis, adaptative immunity and immunological surveillance in peripheral tissues. The regulatory role of nutrition in the CXCR4 expression and immune response are poorly understood. In the present study, we investigated the CXCR4 receptor expression in splenocytes and thymocytes of protein restricted mice infected with Listeria monocytogenes. Lymphocyte subsets and chemokine receptors were analysed by flow cytometry. Our results demonstrated higher levels of expression of the CXCR4 receptor in thymus in comparison with spleen. Infection induced significant changes in the CXCR4 expression levels and it was observed that the expression profile is affected by the level of protein intake.
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