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- Julio C. Calvo, Juan C. Martínez, Manuel E. Patarroyo, Arnold C. Satterthwait, FROM PREDICTION TO ANTIGENIC ANALYSIS: IN THE FOOTPRINTS OF A CONFORMATIONAL EPITOME , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 27 No. 102 (2003)
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Two analogue series of a peptide sequence from the 42 kD fragment of Plasmodium falciparum MSP-1 protein were synthesized by systematically replacing each one of the positions by aspartic acid or lysine to study the physical adsorption phenomenon. Such modifications showed a nonregular tendency regarding solubility and adsorption data. The aspartic acid best adsorption data was obtained by substituting aspartic acid in position 6, and the worst in position 5; however, no significant structural differences were found between these analogue peptides. Decreasing adsorption values in the lysine analogue series, indicate that adsorption into aluminium hydroxide is predominantly guided by electrostatic effects.
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