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Abstract
From the methanolic extract of the Anacardium giganteum nut, the following compounds: 5-[8’(Z),11’(Z),14-pentadecatrienyl]resorcinol 1, 5-[8’(Z),11’(Z)-pentadecadienyl]resorcinol 2, 5-[8’(Z)-pentadecenyl]resorcinol 3, 6-[8’(Z),11’(Z),14-pentadecatrienyl]salicylic acid 4, 6-[8’(Z),11’(Z)-pentadecadienyl] salicylic acid 5, 6-[8’(Z)-pentadecenyl]salicylic acid 6, 6-pentadecylsalicylic acid 7, naringenin-7-(6”-O-p-cumaroyl)-β-D-glucopyranoside 8 and naringenin-7-O-β-D-glucopyranoside 9, were isolated and identified by spectroscopic techniques (MS, 1 H and 13 C NMR). It is important to note that this is the first time that the unequivocal assignment of 1 H and 13 C NMR signals of compound 8 is made on the basis on its HMQC and HMBC spectra. This is also the first time that cytotoxic activity of compounds 1 – 9 against human tumor cell lines HEp-2, MCF-7, HT-29 and MKN-45 is evaluated. In these assays, compounds 1 – 3 and 8 were active against the above-mentioned cell lines.
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References
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