Nobel 2024 in Physiology or Medicine for microRNAs

Lee RC, Feinbaum RL, Ambros V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 75(5), 43-54. PMID: 8252621.

Moss EG, Lee RC, Ambros V. (1997). The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell, 88(5):637-646. PMID: 9054503.

Nobel Foundation, The Nobel Committee for Medicine, The Royal Swedish Academy of Sciences (2024). https://www.nobelprize.org/prizes/medicine/2024/advanced-information/

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature, 408(6808), 86-89 - PMID: 11081512 – https://doi.org/10.1038/35040556

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. (2000). The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature, 403(6772), 901-906. PMID: 10706289 - https://doi.org/10.1038/35002607