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Las estatinas se han usado ampliamente en el tratamiento de la hipercolesterolemia y otras enfermedades cardiovasculares. Recientemente se han estudiado sus efectos apoptóticos, lo que las hace relevantes en la prevención y tratamiento del cáncer, aunque sus mecanismos de acción se desconocen. En este estudio empleamos células malignas de osteosarcoma UMR-106 y células normales de trofoblasto extravilloso HTR8/SVneo y encontramos que la simvastatina reduce la viabilidad celular de manera dependiente del tiempo y la dosis, en ambos tipos celulares. Además, mediante FACS se demostró la inducción de apoptosis por simvastatina 10 µM en células trofoblásticas. Por último, el análisis proteómico sugiere un mecanismo regulatorio específico que podría ayudar a explicar los efectos anticancerosos de esta estatina.
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