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A partir de valores de solubilidad a diferentes temperaturas mediante las ecuaciones de Gibbs y van't Hoff se calcularon las funciones termodinámicas, energía libre, entalpía y entropía, para los procesos de solución, mezcla y solvatación de acetaminofén (ACF) en mezclas cosolventes etanol + agua (EtOH + W). La solubilidad fue más alta en mezclas del 90% de EtOH a todas las temperaturas estudiadas, lo que demuestra la importancia del efecto cosolvente en este sistema. La solvatación del fármaco es mayor en la medida que se incrementa la proporción de EtOH en las mezclas. Mediante análisis de compensación entálpica-entrópica se obtuvo un comportamiento más complejo que el descrito previamente en la literatura. Desde el agua pura hasta el 10% m/m de EtOH y desde el 90% de EtOH hasta el etanol puro se encontró una conducción entrópica, mientras que en las otras mezclas se encontró conducción entálpica. Estos hechos podrían explicarse en términos de la pérdida de estructura del agua y en una disminución de la energía de cavidad en el solvente al incrementar la proporción de EtOH. Sin embargo, en las mezclas ricas en EtOH los mecanismos intermoleculares involucrados en el proceso de solución deben ser más complejos involucrando a otras propiedades fisicoquímicas.
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