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- Juan Fernando Duque Osorio, Adalberto Sánchez, Leonardo Fierro, Silverio Garzón, Rafael Santiago Castaño, VENENOS DE SERPIENTES Y MOLÉCULAS ANTIVENENO , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 31 Núm. 118 (2007)
- Juan-Fernando Duque-Osorio, CRESTAS NEURALES, PLACODAS Y ARCOS BRANQUIALES: UNA REVISIÓN EVOLUTIVA Y EMBRIOLÓGICA DE DATOS BÁSICOS Y RECIENTES , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 27 Núm. 103 (2003)
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Los accidentes por mordeduras de serpientes venenosas producen más de 50 mil muertes al año, particularmente en los trópicos donde se han convertido en un problema de salud pública. Estos accidentes producen, entre otros síntomas, hemorragias (SVMPs), mionecrosis (PLAs) y dolor, y las seroterapias convencionales son solo parcialmente efectivas y pueden producir efectos inmunes adversos. Por todo esto, recientemente se están investigando proteínas antiveneno naturales de mamíferos [DM43 (antihemorragina) y DM64 (antimiotóxica) de la zarigüeya] que han demostrado ser más efectivas. Adicionalmente las SVMPs y PLAs venosas tienen sus contrapartes endógenas normales no venenosas (MMPs y PLAs), y cuando el balance entre estas últimas y sus inhibidores se rompe, se producen patologías como: artritis, arterioesclerosis, asma, diabetes, choques sépticos, neoplasias, inflamaciones, psoriasis, reumatismo, etc. Por todo esto se hizo una aproximación in silico y por homología a la estructura 3D de DM64, con el sistema Swiss Model-Deep View. Además de obtener un modelo similar al previamente logrado por otro grupo para DM43, este proceso permitió estandarizar esta técnica de modelamiento de proteínas como una herramienta muy útil en nuestro medio por su eficiencia y bajo costo (SM-DV se puede utilizar gratuitamente).
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