Abstract
Rotavirus enter their host and predominantly replicates in the small intestine. In this organ, TGF-β plays an important role in maintaining tolerance to commensal microorganisms and food. For this reason, it is probable that this citokine plays a role in modulating viral infection. Results from our laboratory have shown that in vitro human cells infected with rotavirus secrete increased levels of TGF-β and promote an attenuated T cell response, which is necessary for protective cellular immunity. In this review article, I will critically evaluate the hypothesis that rotavirus induce the production of TGF-β as an immune evasion mechanism. © 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. All rights reserved.References
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