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- Daniel Ricardo Delgado, María Ángeles Peña, Fleming Martínez, Preferential solvation of some sulfonamides in 1,4-dioxane + water co-solvent mixtures at 298.15 K according to the inverse Kirkwood-Buff integrals method , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 38 No. 146 (2014)
- Miller A. Ruidiaz, Daniel R. Delgado, Fleming Martínez, PERFORMANCE OF THE JOUYBAN-ACREEAND YALKOWSKY-ROSEMAN MODELSFOR ESTIMATING THE SOLUBILITY OFINDOMETHACIN IN ETHANOL + WATERMIXTURES , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 35 No. 136 (2011)
- Diana P. Pacheco, Fleming Martínez, DEVIATIONS FROM YALKOWSKY - ROSEMAN LOG-LINEAR SOLUBILITY EQUATION FOR NAPROXEN IN ETHANOL + WATER COSOLVENT MIXTURES , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 32 No. 124 (2008)
- Fleming Martínez, USEFULNESS OF THE EXTENDED HILDEBRAND SOLUBILITY APPROACH IN THE SOLUBILITY STUDY OF ACETAMINOPHEN IN WATER-L'ROPYLENE GLYCOL SOLVENT MIXTURES , Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales: Vol. 29 No. 112 (2005)
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Abstract
Based on van't Hoff and Gibbs equations the thermodynamic functions free energy, enthalpy, and entropy of solution, mixing and solvation of acetaminophen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at several temperatures. The solubility was greater at 90% m/m of ethanol at all temperatures studied. This result shows clearly the cosolvent effect present in this system. The solvation of this drug in the mixtures increases as the ethanol proportion is also increased. By means of enthalpy-entropy compensation analysis, a more complex behavior for solution was found with respect to that exposed previously in literature. From 0% up to 10% m/m of ethanol and from 90% up to 100% of ethanol, entropy driving was found, while from 20% up to 60% of ethanol, enthalpy driving was found. These facts would be explained in terms of a losing of water-structure in addition to a diminishing in the energy required for cavity formation in the solvent for mixtures from 20% up to 60% of ethanol. Nevertheless in the ethanol-rich mixtures the intermolecular mechanisms involved in the solution process should be more complex including other physicochemical considerations.
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