Abstract
The etiology and pathogenesis of asthma cases involve an allergic mechanism. Allergens from house dust mites are the main cause of asthma within a genetically susceptible population. B. tropicalis and D. pteronyssinus are the commonest domestic mites in the tropics. During this decade, important advances have been made in our laboratory, in regard to the clinical role of B. tropicalis. Here we describe the general approach and results we have obtained in the immunochemical and molecular characterization of several allergens from this mite. This goal includes the possibility of genetic manipulation of the cloned allergens to get safe reagents for diagnosis and Immunotherapy of allergic diseases.
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References
Arlian L, Vyszenski-Moher D, & Fernández-Caldas E. 1993. Allergenicity of the mite, Blomia tropicalis. J Allergy Clin Immunol 91:1042-50.
Arruda K, Rizzo M, Chapman M, Fernández-Caldas E, Baggio D, Platts-Mills T, & Naspitz C. 1991. Exposure and sensitization to house dust mite allergens among asthmatic children in Sao Paulo, Brazil. Clin Exp Allergy 21: 433-439
Arruda K, Valles L, Platts-Mills T, Fernández-Caldas E, Montealegre F, Lin K, Chua K, Rizzo M, Naspitz C, & Chapman M. 1997. Sensitization to Blomia tropicalis in patients with asthma and identification of allergen Blot 5. Am J Resp Crit Care med 155: 342-350.
Bavbek S, Valles L., Wah L., Arruda L, & Chapman M. 1997. Development of an ELISA for recombinant Blomia tropicalis allergen, Blot 5: use in monitoring environment allergen exposure. J Allergy Clin Immunol (Abstract) 99: S162.
Caraballo L, Puerta L, Fernandez-Caldas E, Lockey R, & Martínez B. 1998. Sensitization to mite allergens and acute asthma in a tropical environment. J Invest Allergol Clin Immunol 8.
Caraballo L, Avgioglu A, Marrugo J, Puerta L, & Marsh D. 1996. Cloning and expression of cDNA coding for an allergen with common antibody binding specificities with three allergens of the house dust mite Blomia tropicalis. J. Allergy Clin Immunol 98: 573-579.
Caraballo L, Puerta L, Martínez B, & Moreno L. 1994. Identification of allergens from the mite Blomia tropicalis. Clin Exp Allergy 24:1056-1060.
Caraballo L, Lagares A, Mercado D, Puerta L, & Fernández-Caldas E. 1999. Sensitization to the mite Suidasia medanensis in asthmatic patients. J Allergy Clin Immunol (Abstract) 103:189.
Caraballo L, Mercado D, Jiménez S, Moreno L, & Puerta L. 1998. Analysis of the cross-reactivity between BtM and Der p 5, two Group 5 recombinant allergens from Blomia tropicalis and Dermatophagoides pteronyssinus. Int Arch Allergy Immunol 117:38-45
Caraballo L. 1999. The influence on genes on the etiology of asthma. Allergy and Clin Immunol International. 11: In press.
Caraballo L, Cadavid A, & Mendoza J. 1992. The prevalence of asthma in a tropical city of Colombia. Annals of Allergy 68:525-529.
Caraballo L, Puerta L, Jiménez S, Martínez B, Mercado D, Avgiouglu A, & Marsh D. 1997. Cloning and IgE binding of a recombinant allergen from the mite Blomia tropicalis, homologous with fatty acid-binding proteins. Int Arch Allergy Immunol 1997; 112: 341-347.
Ferrandiz R, & Casas R, Dreborg S. 1998. Cross-reactivity between Dermatophagoides siboney and other domestic mites. Int Arch Allergy Immunol 116:206-214
Fernández-Caldas E, Baena-Cagnani C, López M, Patiño C, Neffen H, Sánchez-Medina M, Caraballo L, Huerta J, Malka S, Naspitz C, & Lockey R. 1993. Cutaneous sensitivity to six mite species in asthmatic patients from five Latin American countries. J Invest Allergol Clin Immunol 3:245-249
Ferrandiz R, Casas R, & Dreborg S. 1996. Sensitization to Dermatophagoides sybonei, Blomia tropicalis and other domestic mites in asthmatic patients. Allergy 51:501-505
Ferrandiz R, Casas R, Dreborg S, Einarsson R, & Fernández B. 1995. Crossreactivity between Dermatophagoides siboney and other house dust mite allergens in sensitized asthmatic patients. Clin Exp Allergy 25:929-934
Johansson E, Schmidt M, Johansson S, Machado L, Olsson S, & van Hage-Hastem M. 1997. Allergenic cross-reactivity between Lepidoglyphus destructor and Blomia tropicalis. Clin Exp Allergy 27:691-699
Lee B. 1997. An evaluation of indoor allergens and the efficacy of allergen control modalities in Singapore. Singapore Paediatric Journal 39(Suppl):8-27
Moreno L, Hamilton R, Rafnar T, Jiménez S, Marsh D, & Caraballo L. 1997. Identification of an IgE-binding epitope of a recombinant allergen from the mite Blomia tropicalis (Bt). J Allergy Clin Immunol [Abstract] 99:8351
Nelson R, DiNicolo R, Fernández-Caldas E, SeleznickM, Lockey R, & Good R. 1996. Allergen-specific IgE levels and mite allergen exposure in children with acute asthma first seen in an emergency department and in non asthmatic control subjects. J Allergy Clin Immunol 98:258-263
Oconnor B. 1982. Astigmata. in: Parker S (ed): Synopsis and Classification of living Organisms. Vol 2. New York, Mc Graw Hill, 1982, pp 146-169.
Portus M, Blasco C, & Fontarnau R. 1976. Presencia en España de Blomia tropicalis (Bronswijk, Cock y Oshima, 1973, Glycyphagidae, sarcoptiformes) y estudio de su morfologia al SEM. Rev Iber Parasitol 36:175-180
Puerta L, Jiménez S, Lagares A, & Caraballo L. 1999. High level expression of the Blomia tropicalis allergen, Blo t 13, in Pichia pastoris. J Allergy Clin Immunol (Abstract) 103:S185
Puerta L, Kennedy M, Jiménez S, & Caraballo L. 1999. Structural and ligand binding analysis of recombinant Blot 13 allergen from Blomia tropicalis mite, a fatty acid-binding protein. Int Archives Allergy Immunol 119: En Prensa
Puerta L., Fernández-Caldas E, Lockey R, & Caraballo L. 1993. Mite allergy in the tropics: Sensitization to six domestic mite species in Cartagena, Colombia. J Invest Allergol Clin Immunol 3:198-204 Puerta L, Caraballo L, Fernández-Caldas E, Avjioglu A, Marsh D, Lockey R, & Dao M. 1996. Nucleotide sequence analysis of a complementary DNA coding for a Blomia tropicalis allergen. J Allergy Clin Immunol 98:932-937
Puerta L, Fernández-Caldas E, Mercado D, Lockey R, & Caraballo L. 1996. Sequential determinations of Blomia tropicalis allergens in mattress and floor dust samples in a tropical city. J Allergy Clin Immunol 97:689-91
Puerta L, Fernández-Caldas E, Caraballo L, & Lockey R. 1991. Sensitization to Blomia tropicalis and Lepidoglyphus destructor in Dermatophagoides spp-allergic individuals. J Allergy Clin Immunol 88:943-950
Rizzo M, Fernández-Caldas E, Sole D, & Naspitz C. 1997. IgE antibodies to aeroallergens in allergic children in Sao Paulo, Brazil. J Investig Allergol Clin Immunol 7:242-248
Simpson A, Arruda K, & Chapman M. 1997. Antigenic Interrelationships among mite allergens (Blomia and Dermatophagoides spp). Clin Rev Allergy Immunol 15:461-469
W, Lockey Stanaland B, Fernández-Caldas E, Jacinto C, & Trudeau R. 1994. Sensitization to Blomia tropicalis: Skin test and cross- reactivity studies. J Allergy Clin Immunol 94:452-457
Stanaland B, Fernández-Caldas E, Jacinto C, Trudeau W, & Lockey R. 1996. Positive nasal challenge responses to Blomia tropicalis. J Allergy Clin Immunol 97:1045-9
Tsai J, Wu H, Shen D, Hsu E, & Wang S. 1998. Sensitization to Blomia tropicalis among asthmatic patients in Taiwan. Int Arch Allergy Immunol 115:144-149
Vergara C, Caraballo L. 1998. Asthma mortality in Colombia. Ann Allergy Asthma Immunol. 80:55-60.
Zhang L, Chew F, Soh S, Yi F, Law S, Goh D, & Lee B. 1997. Prevalence and distribution of indoor allergens in Singapore. Clin Exp Allergy 27:876-885.
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